HSL is to run a 2 day course on Derivation of a Derived No-Effect Level Using PBPK and Benchmark Dose Response Modelling.

This course will be held at the Health and Safety Laboratory, Harpur Hill, Buxton, Derbyshire.

Please enquire: training@hsl.gov.uk

Introduction

The risk to humans from exposure to chemicals is considered controlled if the level of exposure does not exceed an appropriate health based value such as, the derived no-effect level (DNEL) under REACH and guidance values under the Biocides Directive and Plant Protection Products Directive.  However, several quite different health based values may be determined from the same animal toxicology data. This can lead to disputes between industry and regulator.

This course is designed to introduce participants to the application of user-friendly tools for quantitative, data-informed chemical risk assessment, which have the potential to reduce the uncertainties associated with inter-species extrapolation and the use of in vitro data. The participants will use physiologically based pharmacokinetic (PBPK) modelling to convert administered doses to organ and tissue concentrations, benchmark dose response modelling and apply inter- and intra-species assessment factors to derive a DNEL.

The course will cover:

• Tools for use in quantitative, data-informed chemical risk assessment.
• An approach for the derivation of a DNEL for a chemical with a demonstrable threshold.
• The fundamental concepts underlying PBPK modelling.
• The rapid construction of PBPK models using a user-friendly model equation generator and visualizing model output using the software, Berkeley Madonna®.

Presenters include:

Dr.George Loizou a biochemical toxicologist with over 22 years experience in quantitative, mechanistic toxicology.

Keynote speaker - M.E. (Bette) Meek, Associate Director, Chemical Risk Assessment McLaughlin Institute for Population Health Risk Assessment University of Ottawa.

Who should attend?

• Industrial professionals responsible for conducting or evaluating risk assessments on consumer, environmental and occupational exposure to chemicals.
• Occupational health and safety professionals.
• Scientists interested in physiologically based pharmacokinetic modelling.

Venue

The course will be run at the HSL laboratory in the spa town of Buxton. Buxton is in the heart of the Peak District and has good links to mainline train stations and Manchester International Airport.

The cost of the two-day course is £995 + VAT (to include course notes, lunches, refreshments and dinner on the first night).

For further information email: training@hsl.gov.uk or contact the Training Unit at HSL directly on 01298 218806.

Details of hotels in the Buxton area can be found at www.visitpeakdistrict.com

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